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Nippoldt, M.D. Be wary of any product that claims to be a natural form of Viagra.In the United States, Pfizer received two patents for sildenafil: one for its indication to treat cardiovascular disease (marketed as Revatio) and another for its indication to treat erectile dysfunction (marketed as Viagra).Other drugs that operate by the same mechanism include tadalafil (Cialis) and vardenafil (Levitra).Caution is advised in those who have cardiovascular disease.This metabolite also has an affinity for the PDE receptors, about 40% of that of sildenafil.

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Medications used in the management of pulmonary arterial hypertension ( B01, C02 ).Men with low testosterone levels who suffer from erectile dysfunction and have tried Viagra without success may benefit from adding a testosterone gel to.Our Pharmacy offers wide variety of generic viagra online and cheap levitra.It requires vision, leadership and talented people to make it all happen.

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Sildenafil should not be used if sexual activity is inadvisable due to underlying cardiovascular risk factors (such as recent heart surgery, stroke or heart attack, etc.).There are also mouth spray preparations of sildenafil for faster onset of action.

Help About Wikipedia Community portal Recent changes Contact page.In February 2007, it was announced that Boots, the UK pharmacy chain, would try over-the-counter sales of Viagra in stores in Manchester, England.Trade names include Kamagra ( Ajanta Pharma ), Silagra ( Cipla ), Edegra ( Sun Pharmaceutical ), Penegra ( Zydus Cadila ), and Zenegra ( Alkem Laboratories ).Furchgott, Ferid Murad, and Louis Ignarro won the Nobel Prize in Physiology or Medicine in 1998 for their independent study of the metabolic pathway of nitric oxide in smooth muscle vasodilation.The major product of metabolisation by these enzymes is N-desmethylated sildenafil, which is metabolised further.

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The patent on Revatio (indicated for pulmonary arterial hypertension rather than erectile dysfunction) expired in late 2012.

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Nitric oxide (NO) in the corpus cavernosum of the penis binds to guanylate cyclase receptors, which results in increased levels of cGMP, leading to smooth muscle relaxation ( vasodilation ) of the intimal cushions of the helicine arteries.See how Viagra fixes erectile dysfunction, what causes the dysfunction and known side effects of Viagra.

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Psychostimulants (e.g., amphetamines, cocaine, methylphenidate ).

Sildenafil is broken down in the liver by hepatic metabolism using cytochrome p450 enzymes, mainly CYP450 3A4(major route), but also by CYP2C9 (minor route) hepatic isoenzymes.Rare but serious side effects include prolonged erections, which can lead to damage to the penis, and sudden-onset hearing loss.

Scientists and engineers are trying inventions such as artificial trees to pull carbon dioxide out of the atmosphere.The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse).Viagra Brand Name Viagra Common Name sildenafil In this drug factsheet: How does this medication work.

By using this site, you agree to the Terms of Use and Privacy Policy.Main page Contents Featured content Current events Random article Donate to Wikipedia Wikipedia store.Methylation of 3-propylpyrazole-5-carboxylic acid ethyl ester with hot dimethyl sulfate.Sildenafil is a potent and selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum.What links here Related changes Upload file Special pages Permanent link Page information Wikidata item Cite this page.

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It was initially studied for use in hypertension (high blood pressure) and angina pectoris (a symptom of ischaemic heart disease ).