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The frequent side effects are stomach upset, headache, flushing, heartburn, nasal stuffiness, dizziness or diarrhea, irregular heartbeat, shortness of breath, prolonged (longer than 4 hours), or painful erection.Rare but serious side effects include prolonged erections, which can lead to damage to the penis, and sudden-onset hearing loss.Sildenafil Citrate can be used for pulmonary arterial hypertension treating.Furchgott, Ferid Murad, and Louis Ignarro won the Nobel Prize in Physiology or Medicine in 1998 for their independent study of the metabolic pathway of nitric oxide in smooth muscle vasodilation.

Sildenafil acts by inhibiting cGMP-specific phosphodiesterase type 5 (phosphodiesterase 5, PDE 5 ), an enzyme that promotes degradation of cGMP, which regulates blood flow in the penis.This metabolite also has an affinity for the PDE receptors, about 40% of that of sildenafil.Other drugs that operate by the same mechanism include tadalafil (Cialis) and vardenafil (Levitra).Medications used in the management of pulmonary arterial hypertension ( B01, C02 ).Sildenafil protects cyclic guanosine monophosphate (cGMP) from degradation by cGMP-specific phosphodiesterase type 5 (PDE5) in the corpus cavernosum.The information is reliable, but we concede it could contain mistakes.

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Sildenafil is excreted as metabolites predominantly in the feces (about 80% of administered oral dose) and to a lesser extent in the urine (around 13% of the administered oral dose).

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Professional athletes have been documented using sildenafil, believing the opening of their blood vessels will enrich their muscles.Sildenafil is broken down in the liver by hepatic metabolism using cytochrome p450 enzymes, mainly CYP450 3A4(major route), but also by CYP2C9 (minor route) hepatic isoenzymes.

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Help About Wikipedia Community portal Recent changes Contact page.Protease inhibitors inhibit the metabolism of sildenafil, effectively multiplying the plasma levels of sildenafil, increasing the incidence and severity of side effects.

There are also mouth spray preparations of sildenafil for faster onset of action.

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Concomitant use of soluble guanylyl cyclase stimulators, such as riociguat.See also: Drugs for erectile dysfunction and premature ejaculation.If you notice other side effects not listed above, you should contact your doctor or pharmacist.

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Order generic viagra, viagra tablets for sale Cheap brand free pills tablet buy line cheapest canada without prescription stores generic, sildenafil 100mg.Psychostimulants (e.g., amphetamines, cocaine, methylphenidate ).Scientists and engineers are trying inventions such as artificial trees to pull carbon dioxide out of the atmosphere.

Middle aged people can be more sensitive to side effects of the medicine.Common side effects include headaches and heartburn, as well as flushed skin.

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Before starting the treatment with Sildenafil Citrate, tell your doctor or health care adviser about any allergy you have.Sildenafil, sold as the brand name Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension.

The patent on Revatio (indicated for pulmonary arterial hypertension rather than erectile dysfunction) expired in late 2012.