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Psychostimulants (e.g., amphetamines, cocaine, methylphenidate ).

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Sildenafil acts by inhibiting cGMP-specific phosphodiesterase type 5 (phosphodiesterase 5, PDE 5 ), an enzyme that promotes degradation of cGMP, which regulates blood flow in the penis.

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Protease inhibitors inhibit the metabolism of sildenafil, effectively multiplying the plasma levels of sildenafil, increasing the incidence and severity of side effects.

In the United States, Pfizer received two patents for sildenafil: one for its indication to treat cardiovascular disease (marketed as Revatio) and another for its indication to treat erectile dysfunction (marketed as Viagra).It was initially studied for use in hypertension (high blood pressure) and angina pectoris (a symptom of ischaemic heart disease ).Kannada Tablets Viagra Citrate To Sildenafil In How Tablets Jaguar Use.Nitric oxide (NO) in the corpus cavernosum of the penis binds to guanylate cyclase receptors, which results in increased levels of cGMP, leading to smooth muscle relaxation ( vasodilation ) of the intimal cushions of the helicine arteries.

There are also mouth spray preparations of sildenafil for faster onset of action.Drugs for erectile dysfunction ( G04BE ) and premature ejaculation.

In February 2007, it was announced that Boots, the UK pharmacy chain, would try over-the-counter sales of Viagra in stores in Manchester, England.Care should be exercised by people who are also taking protease inhibitors for the treatment of HIV infection.

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This metabolite also has an affinity for the PDE receptors, about 40% of that of sildenafil.

Scientists and engineers are trying inventions such as artificial trees to pull carbon dioxide out of the atmosphere.Viagra at The Periodic Table of Videos (University of Nottingham).Medications used in the management of pulmonary arterial hypertension ( B01, C02 ).Other drugs that operate by the same mechanism include tadalafil (Cialis) and vardenafil (Levitra).Help About Wikipedia Community portal Recent changes Contact page.

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Rare but serious side effects include prolonged erections, which can lead to damage to the penis, and sudden-onset hearing loss.What links here Related changes Upload file Special pages Permanent link Page information Wikidata item Cite this page.

Sildenafil is a potent and selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum.Learn what to discuss and how you should take the drug Viagra (Sildenafil Citrate). Like Us. Viagra Patient Information including How Should I Take.

Methylation of 3-propylpyrazole-5-carboxylic acid ethyl ester with hot dimethyl sulfate.I Can To In Use Video How Viagra Tablets Get Where Viagra Pakistan.Sildenafil is excreted as metabolites predominantly in the feces (about 80% of administered oral dose) and to a lesser extent in the urine (around 13% of the administered oral dose).

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