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Sildenafil protects cyclic guanosine monophosphate (cGMP) from degradation by cGMP-specific phosphodiesterase type 5 (PDE5) in the corpus cavernosum.Action Of Viagra Buy Pharmacological Cialisnarodru The Cialis.

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Nitric oxide (NO) in the corpus cavernosum of the penis binds to guanylate cyclase receptors, which results in increased levels of cGMP, leading to smooth muscle relaxation ( vasodilation ) of the intimal cushions of the helicine arteries.

Professional athletes have been documented using sildenafil, believing the opening of their blood vessels will enrich their muscles.

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Help About Wikipedia Community portal Recent changes Contact page.It was initially studied for use in hypertension (high blood pressure) and angina pectoris (a symptom of ischaemic heart disease ).This metabolite also has an affinity for the PDE receptors, about 40% of that of sildenafil.Research suggests that there is an association between side effects of Viagra and melanoma, with some studies finding that users of the medication may be 84% more likely to develop the serious and potentially deadly skin cancer.Find out what health conditions may be a health risk when taken with Viagra oral.Researchers reviewed data involving more than 25,000 men who were followed for ten years.

In February 2007, it was announced that Boots, the UK pharmacy chain, would try over-the-counter sales of Viagra in stores in Manchester, England.

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Viagra official prescribing information for healthcare professionals.Sildenafil is excreted as metabolites predominantly in the feces (about 80% of administered oral dose) and to a lesser extent in the urine (around 13% of the administered oral dose).

There are also mouth spray preparations of sildenafil for faster onset of action.A free collection of articles about Viagra (Drug) published in The New York Times.Stores Pharmacy Viagra And And Online Viagra Xanax Pharmacies.

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Caution is advised in those who have cardiovascular disease.

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