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Sildenafil is excreted as metabolites predominantly in the feces (about 80% of administered oral dose) and to a lesser extent in the urine (around 13% of the administered oral dose).

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There are also mouth spray preparations of sildenafil for faster onset of action.It was initially studied for use in hypertension (high blood pressure) and angina pectoris (a symptom of ischaemic heart disease ).See how Viagra fixes erectile dysfunction, what causes the dysfunction and known side effects of Viagra.In the United States, Pfizer received two patents for sildenafil: one for its indication to treat cardiovascular disease (marketed as Revatio) and another for its indication to treat erectile dysfunction (marketed as Viagra).

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Sildenafil protects cyclic guanosine monophosphate (cGMP) from degradation by cGMP-specific phosphodiesterase type 5 (PDE5) in the corpus cavernosum.Of Pharmacy From The Buying Viagra Dangers Price Online Viagra.

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Rare but serious side effects include prolonged erections, which can lead to damage to the penis, and sudden-onset hearing loss.Care should be exercised by people who are also taking protease inhibitors for the treatment of HIV infection.

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Learn about Viagra (Sildenafil Citrate) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.Our clinicians regularly offer patients the opportunity to take part in trials of new drugs and treatments.Sildenafil is broken down in the liver by hepatic metabolism using cytochrome p450 enzymes, mainly CYP450 3A4(major route), but also by CYP2C9 (minor route) hepatic isoenzymes.

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Medications used in the management of pulmonary arterial hypertension ( B01, C02 ).Drugs for erectile dysfunction ( G04BE ) and premature ejaculation.

Help About Wikipedia Community portal Recent changes Contact page.Sildenafil acts by inhibiting cGMP-specific phosphodiesterase type 5 (phosphodiesterase 5, PDE 5 ), an enzyme that promotes degradation of cGMP, which regulates blood flow in the penis.Levitra Sales 2017 - Viagra Spot Pub Levitra Sales 2017 Viagra Pharmacist Hyderabad Natural Cialis Alternatives.Furchgott, Ferid Murad, and Louis Ignarro won the Nobel Prize in Physiology or Medicine in 1998 for their independent study of the metabolic pathway of nitric oxide in smooth muscle vasodilation.What links here Related changes Upload file Special pages Permanent link Page information Wikidata item Cite this page.Trade names include Kamagra ( Ajanta Pharma ), Silagra ( Cipla ), Edegra ( Sun Pharmaceutical ), Penegra ( Zydus Cadila ), and Zenegra ( Alkem Laboratories ).

This metabolite also has an affinity for the PDE receptors, about 40% of that of sildenafil.

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In February 2007, it was announced that Boots, the UK pharmacy chain, would try over-the-counter sales of Viagra in stores in Manchester, England.Protease inhibitors inhibit the metabolism of sildenafil, effectively multiplying the plasma levels of sildenafil, increasing the incidence and severity of side effects.