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Sildenafil, sold as the brand name Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension.

Sildenafil is excreted as metabolites predominantly in the feces (about 80% of administered oral dose) and to a lesser extent in the urine (around 13% of the administered oral dose).

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Sildenafil Citrate Mouth Dissolving Tablets. 25 Mg Viagra Cost.Common side effects include headaches and heartburn, as well as flushed skin.

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Nhs Cost Of Viagra. 100 Sildenafil Nhs Of Mg Cost Viagra Tablets.Viagra (sildenafil) is by much the most popular prescribed medicine used to manage male impotence (or impotence) in people of all ages,.

In the United States, Pfizer received two patents for sildenafil: one for its indication to treat cardiovascular disease (marketed as Revatio) and another for its indication to treat erectile dysfunction (marketed as Viagra).Information about Viagra including how Viagra works, dosage, how much Viagra costs, and side effects of Viagra.

The major product of metabolisation by these enzymes is N-desmethylated sildenafil, which is metabolised further.It was initially studied for use in hypertension (high blood pressure) and angina pectoris (a symptom of ischaemic heart disease ).

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Our clinicians regularly offer patients the opportunity to take part in trials of new drugs and treatments.Psychostimulants (e.g., amphetamines, cocaine, methylphenidate ).There are also mouth spray preparations of sildenafil for faster onset of action.

What Is The Cost Of Viagra Tablets In India - Viagra Canadianpharmacies What Is The Cost Of Viagra Tablets In India Online Pharmacies Viagra Cialis 5mg Original Kaufen.Sildenafil should not be used if sexual activity is inadvisable due to underlying cardiovascular risk factors (such as recent heart surgery, stroke or heart attack, etc.).Viagra at The Periodic Table of Videos (University of Nottingham).

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Sildenafil is a potent and selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum.

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This metabolite also has an affinity for the PDE receptors, about 40% of that of sildenafil.

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Sildenafil acts by inhibiting cGMP-specific phosphodiesterase type 5 (phosphodiesterase 5, PDE 5 ), an enzyme that promotes degradation of cGMP, which regulates blood flow in the penis.

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Furchgott, Ferid Murad, and Louis Ignarro won the Nobel Prize in Physiology or Medicine in 1998 for their independent study of the metabolic pathway of nitric oxide in smooth muscle vasodilation.

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Rare but serious side effects include prolonged erections, which can lead to damage to the penis, and sudden-onset hearing loss.

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Sildenafil is broken down in the liver by hepatic metabolism using cytochrome p450 enzymes, mainly CYP450 3A4(major route), but also by CYP2C9 (minor route) hepatic isoenzymes.